Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552774 | 0.90 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL1862476 | 0.86 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5557065 | 0.85 | MEN1 (0.40) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL5552928 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5753365 | 0.81 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL1864760 | 0.81 | MEN1 (0.42) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL5557057 | 0.80 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5753323 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL1864877 | 0.77 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5557124 | 0.76 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161671-A1 | 7-Azaindoles and the use thereof as therapeutic agents | BIOTIE THERAPIES GMBH (DE) | 2007-07-12 | — | — | US | claimed |
| JP-2006524209-A | — | — | 2006-10-26 | — | — | JP | claimed |
| EP-1613627-A1 | 7-AZAINDOLES AND USE THEREOF AS THERAPEUTIC AGENTS | Elbion AG (DE) | 2006-01-11 | — | — | EP | claimed |
| US-20040224971-A1 | 7-azaindoles and the use thereof as therapeutic agents | BIOTIE THERAPIES GMBH (DE) | 2004-11-11 | — | — | US | claimed |
| WO-2004094416-A1 | 7-AZAINDOLES AND USE THEREOF AS THERAPEUTIC AGENTS | ELBION AG (DE) | 2004-11-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224971-A1 | 7-azaindoles and the use thereof as therapeutic agents | PDE4B, PDE4A, PDE4D | PDE4A 2/4885PDE4B 1/4885PDE4C 4/4885 |
| US-20070161671-A1 | 7-Azaindoles and the use thereof as therapeutic agents | PDE4B, PDE4A, PDE4D | PDE4A 2/4885PDE4B 1/4885PDE4C 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.