Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759222 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5468791 | 0.87 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5759099 | 0.87 | TUBB4A (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5756921 | 0.87 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL5756186 | 0.86 | MEN1 (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5753323 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5557057 | 0.84 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5468831 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5755902 | 0.83 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5756693 | 0.82 | CNR1 (0.46) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615912-A1 | 4-, 6- O 7-HYDROXYINDOLES HAVING N-OXIDE GROUPS AND THE USE THEREOF AS THERAPEUTIC AGENTS | Elbion AG (DE) | 2006-01-18 | — | — | EP | claimed |
| US-20040242643-A1 | 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | ELBION AG (DE) | 2004-12-02 | — | — | US | claimed |
| WO-2004094405-A1 | 4-, 6- O 7-HYDROXYINDOLES HAVING N-OXIDE GROUPS AND THE USE THEREOF AS THERAPEUTIC AGENTS | ELBION AG (DE) | 2004-11-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242643-A1 | 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | PDE4A, HNMT, PDE4B | PDE4A 1/4885PDE4B 3/4885PDE4C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.