Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | DRD1 | P21728 | 4/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | HRH1 | P35367 | 4/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14364964 | 0.93 | CHRM1 (0.40) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL5564017 | 0.93 | CHRM1 (0.39) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL5564014 | 0.93 | CHRM1 (0.39) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL5564191 | 0.90 | CHRM1 (0.36) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| SCHEMBL14156771 | 0.88 | CHRM1 (0.43) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL4836391 | 0.87 | CHRM1 (0.43) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| SCHEMBL5557356 | 0.87 | DRD2 (0.43) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL4836401 | 0.87 | CHRM1 (0.43) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| SCHEMBL5559544 | 0.87 | CHRM1 (0.43) | CHRM1DRD2KCNH2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL6449745 | 0.86 | DRD2 (0.42) | CHRM1DRD2KCNH2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492794-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | LILLY CO ELI (US) | 2007-12-12 | — | — | EP | claimed |
| US-20050203296-A1 | For therapy of psychosis and bipolar disorder | ELI LILLY AND COMPANY | 2005-09-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203296-A1 | For therapy of psychosis and bipolar disorder | DRD4, AFF4, DRD2 | CHRM1 203/4885DRD2 3/4885KCNH2 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.