Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392849 | 0.89 | MAP2K1 (0.83) | MAP2K1MEN1KMT2ATDP1RAF1 | |
| SCHEMBL391225 | 0.87 | MAP2K1 (1.00) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL14549245 | 0.81 | MAP2K1 (0.70) | MAP2K1MEN1KMT2ATDP1RAF1 | |
| SCHEMBL392935 | 0.80 | MAP2K1 (0.85) | MAP2K1MEN1KMT2ATDP1RAF1 | |
| SCHEMBL388716 | 0.80 | MAP2K1 (0.69) | MAP2K1MEN1KMT2ATDP1RAF1 | |
| SCHEMBL393781 | 0.79 | MAP2K1 (1.00) | MAP2K1MEN1KMT2ATDP1MAP2K2 | |
| SCHEMBL5563253 | 0.79 | MAP2K1 (0.78) | MAP2K1CSNK2A2MAP2K2 | |
| SCHEMBL393563 | 0.78 | MAP2K1 (0.81) | MAP2K1MEN1KMT2ATDP1RAF1 | |
| SCHEMBL392691 | 0.78 | MAP2K1 (1.00) | MAP2K1MAP2K2 | |
| SCHEMBL387566 | 0.78 | MAP2K1 (0.84) | MAP2K1MEN1KMT2ATDP1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |