Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.78 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | SMC2 | O95347 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.42 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393767 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL393652 | 0.87 | MAP2K1 (0.84) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL392127 | 0.80 | MAP2K1 (0.81) | MAP2K1MAP2K2 | |
| SCHEMBL392797 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL5557673 | 0.79 | MAP2K1 (0.77) | MAP2K1MAP2K2CSNK2A2 | |
| SCHEMBL5497932 | 0.79 | MAP2K1 (0.86) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL392491 | 0.79 | MAP2K1 (0.83) | MAP2K1MAP2K2 | |
| SCHEMBL392789 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2 | |
| SCHEMBL392103 | 0.78 | MAP2K1 (0.79) | MAP2K1MAP2K2 | |
| SCHEMBL391068 | 0.78 | MAP2K1 (0.79) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682138-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1682138-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |