Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 5/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554044 | 0.84 | MEN1 (0.51) | MEN1MAPTKMT2AGAAALDH1A1 | |
| SCHEMBL5558141 | 0.82 | MEN1 (0.62) | MEN1MAPTKMT2APOLBGAA | |
| SCHEMBL1163336 | 0.80 | CYP1B1 (0.69) | MEN1MAPTKMT2ACYP1B1POLB | |
| SCHEMBL661305 | 0.76 | MEN1 (0.55) | MEN1MAPTKMT2APOLBGAA | |
| SCHEMBL5528668 | 0.72 | MEN1 (0.66) | MEN1MAPTKMT2APOLBGAA | |
| SCHEMBL1520828 | 0.72 | ALDH1A1 (0.53) | MEN1MAPTKMT2APOLBTP53 | |
| SCHEMBL3136961 | 0.72 | ALDH1A1 (0.53) | MAPTPOLBTP53METDAO | |
| SCHEMBL3365048 | 0.72 | HDAC6 (0.49) | MEN1MAPTKMT2APOLBTP53 | |
| SCHEMBL28714141 | 0.72 | HDAC3 (0.50) | MEN1MAPTKMT2APOLBTP53 | |
| SCHEMBL7274371 | 0.72 | NPC1 (0.47) | MEN1MAPTKMT2APOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39591-E1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1291351-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1291353-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-0929563-B1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LAB (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1291352-B1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291350-B1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1291351-A1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291352-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291350-A1 | 6-0 substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1291353-A1 | 6-O-substituted ketolides having antibacterial activity | ABBOTT LABORATORIES (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6147197-A | INCREASED ACID STABILITY AND ENHANCED ACTIVITY TOWARD GRAM NEGATIVE BACTERIA AND MACROLIDE RESISTANT GRAM POSITIVE BACTERIA | ABBVIE INC. | 2000-11-14 | — | — | US | disclosed |
| US-6075133-A | INCREASED ACID STABILITY AND ENHANCED BACTERICIDAL ACTIVITY | ABBOTT LABORATORIES (US) | 2000-06-13 | — | — | US | disclosed |
| US-6028181-A | 6-0-Substituted antibacterial erythromycin ketolides and methods of making | ABBOTT LABORATORIES (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0929563-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | Abbott Laboratories (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5866549-A | MACROLIDE ANTIBIOTICS | ABBOTT LABORATORIES (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1998009978-A1 | 6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY | ABBOTT LABORATORIES (US) | 1998-03-12 | — | — | WO | disclosed |