Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15233334 | 0.93 | BRD4 (0.52) | BRD4RHEBKDM4EALDH1A1RAB9A | |
| SCHEMBL7470356 | 0.88 | TDP1 (0.48) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL5559865 | 0.81 | MEN1 (0.47) | BRD4RHEBKDM4EALDH1A1RAB9A | |
| SCHEMBL8604250 | 0.81 | HSP90AA1 (0.59) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL7467214 | 0.80 | MAPT (0.38) | ALDH1A1RAB9AHPGDLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7466054 | 0.79 | FLT3 (0.38) | KDM4ERAB9APKMMMP2MMP9 | |
| SCHEMBL1170648 | 0.78 | KDM4E (0.61) | BRD4RHEBKDM4EALDH1A1RAB9A | |
| SCHEMBL6523273 | 0.78 | PKN1 (0.38) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL5559555 | 0.77 | KMT2A (0.34) | BRD4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL8610747 | 0.77 | NPBWR1 (0.60) | RHEBKDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524899-B2 | Oligopeptide containing fused 6-membered ring forming complexes with double stranded dna; complexes can be used for identification of specific dsDNA sequences, inhibiting gene transcription, therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific gene | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-09-03 | — | — | US | disclosed |
| EP-1599474-B1 | Heterocyclic oligomeric compounds for DNA recognition | CALIFORNIA INST OF TECHN (US) | 2013-04-24 | — | — | EP | disclosed |
| EP-1599474-A4 | ALTERNATIVE HETEROCYCLES FOR DNA RECOGNITION | CALIFORNIA INST OF TECHN (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1599474-A2 | ALTERNATIVE HETEROCYCLES FOR DNA RECOGNITION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050026174-A1 | Alternative heterocycles for DNA recognition | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2005-02-03 | — | — | US | disclosed |
| WO-2004078943-A2 | ALTERNATIVE HETEROCYCLES FOR DNA RECOGNITION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026174-A1 | Alternative heterocycles for DNA recognition | DDB1, PCNA, DNA2 | BRD4 728/4885RHEB 2514/4885KDM4E 4331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.