SCHEMBL5560106

SCHEMBL5560106

CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1CCO

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
ATM Q13315 2/20 0.34
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
TSHR P16473 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HSD17B10 Q99714 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6052721 1.00 ALDH1A1 (0.35) ALDH1A1ATMCHRM2CHRM1CHRM3
SCHEMBL1327198 1.00 ALDH1A1 (0.35) ALDH1A1ATMCHRM2CHRM1CHRM3
SCHEMBL375444 0.91 ALDH1A1 (0.37) ALDH1A1CHRM2CHRM1CHRM3TSHR
SCHEMBL144302 0.91 ALDH1A1 (0.37) ALDH1A1CHRM2CHRM1CHRM3TSHR
SCHEMBL12979137 0.91 ALDH1A1 (0.37) ALDH1A1CHRM2CHRM1CHRM3TSHR
SCHEMBL24411299 0.91 ALDH1A1 (0.37) ALDH1A1CHRM2CHRM1CHRM3TSHR
SCHEMBL142417 0.91 ALDH1A1 (0.37) ALDH1A1CHRM2CHRM1CHRM3TSHR
SCHEMBL29013072 0.87 ALDH1A1 (0.40) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL29013054 0.87 ALDH1A1 (0.40) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL29013043 0.87 ALDH1A1 (0.40) ALDH1A1TSHRMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1729763-A4 NOVEL BICYCLIC COMPOUNDS AS MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD BRISTOL MYERS SQUIBB CO (US) 2007-10-31 EP disclosed
EP-1729763-A2 NOVEL BICYCLIC COMPOUNDS AS MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD Bristol-Myers Squibb Company (US) 2006-12-13 EP disclosed
WO-2005089118-A2 NOVEL BICYCLIC COMPOUNDS AS MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD BRISTOL-MYERS SQUIBB COMPANY (US) 2005-09-29 WO disclosed