Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL787034 | 0.93 | KDM4E (0.67) | POLBKMT2AKDM4EHRH3ALDH1A1 | |
| SCHEMBL3692058 | 0.92 | KMT2A (0.58) | POLBKMT2AKDM4ESMN1; SMN2GRIN1 | |
| SCHEMBL3692055 | 0.92 | KMT2A (0.58) | POLBKMT2AKDM4ESMN1; SMN2GRIN1 | |
| SCHEMBL5561766 | 0.92 | KDM4E (0.65) | POLBKMT2AKDM4ESMN1; SMN2HTT | |
| SCHEMBL14885856 | 0.89 | POLB (0.58) | POLBKMT2AKDM4ESMN1; SMN2HTT | |
| SCHEMBL9995215 | 0.88 | KMT2A (0.60) | POLBKMT2AKDM4ESMN1; SMN2HRH3 | |
| SCHEMBL6483020 | 0.85 | KMT2A (0.51) | POLBKMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6496123 | 0.85 | KMT2A (0.51) | POLBKMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL6483016 | 0.85 | KMT2A (0.51) | POLBKMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL7026318 | 0.83 | KMT2A (0.55) | POLBKMT2AKDM4ESMN1; SMN2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761509-A2 | SUBSTITUTED CYCLOALKYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005111002-A2 | SUBSTITUTED CYCLOALKYL DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |