Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7033938 | 0.93 | GRIN2B (0.53) | KMT2APOLBSMPD1GRIN2BGRIN1 | |
| SCHEMBL5560596 | 0.83 | POLB (0.65) | KMT2APOLBALDH1A1GRIN2BGRIN1 | |
| SCHEMBL6483020 | 0.80 | KMT2A (0.51) | KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6483016 | 0.80 | KMT2A (0.51) | KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6496123 | 0.80 | KMT2A (0.51) | KMT2APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL3692058 | 0.79 | KMT2A (0.58) | KMT2APOLBADRA1DADRA1AADRA1B | |
| SCHEMBL3692055 | 0.79 | KMT2A (0.58) | KMT2APOLBADRA1DADRA1AADRA1B | |
| SCHEMBL787034 | 0.77 | KDM4E (0.67) | KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL5561766 | 0.76 | KDM4E (0.65) | KMT2APOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9995215 | 0.75 | KMT2A (0.60) | KMT2APOLBALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278716-A1 | CYCLOHEXYLAMINE DERIVATIVE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001081295-A1 | CYCLOHEXYLAMINE DERIVATIVE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |