SCHEMBL5561237

SCHEMBL5561237

COC(=O)c1ccc(C(=O)NCCNC(=O)c2ccc(C(=O)OC)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.74
MAPT P10636 2/20 0.68
ALDH1A1 P00352 2/20 0.63
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
CA1 P00915 2/20 0.57
CA2 P00918 2/20 0.57
TDP1 Q9NUW8 1/20 0.57
CA12 O43570 1/20 0.57
CA7 P43166 1/20 0.57
CA9 Q16790 1/20 0.57
CA14 Q9ULX7 1/20 0.57
LMNA P02545 1/20 0.56
LOXL2 Q9Y4K0 1/20 0.55
HPGD P15428 1/20 0.54
TSHR P16473 1/20 0.54
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
ATM Q13315 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5554988 0.92 POLB (0.87) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL4694425 0.90 ALDH1A1 (0.68) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL13753144 0.90 POLB (0.68) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL7462679 0.90 POLB (0.78) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL14424705 0.90 POLB (0.84) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL10874810 0.90 POLB (0.84) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL6539725 0.89 POLB (0.62) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL10652868 0.86 MAPT (0.66) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL1794784 0.86 POLB (1.00) POLBMAPTALDH1A1NPC1RAB9A
SCHEMBL5070260 0.86 ALDH1A1 (0.66) POLBMAPTALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7244792-B2 Process for making a modified thermoplastic polyester STICHTING DUTCH POLYMER INSTITUTE (NL) 2007-07-17 US disclosed
EP-1485423-B1 PROCESS FOR MAKING A MODIFIED THERMOPLASTIC POLYESTER STICHTING DUTCH POLYMER INST (NL) 2007-01-24 EP disclosed
US-20050175783-A1 Process for making a modified thermoplastic polyester STICHTING DUTCH POLYMER INSTITUTE (NL) 2005-08-11 US disclosed
EP-1485423-A1 PROCESS FOR MAKING A MODIFIED THERMOPLASTIC POLYESTER Stichting Dutch Polymer Institute (NL) 2004-12-15 EP disclosed
WO-2003078502-A1 PROCESS FOR MAKING A MODIFIED THERMOPLASTIC POLYESTER STICHTING DUTCH POLYMER INSTITUTE (NL) 2003-09-25 WO disclosed
EP-0724568-B1 AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING UNILEVER PLC (GB) 1998-11-04 EP disclosed
EP-0724568-A1 AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING UNILEVER PLC (GB) 1996-08-07 EP disclosed
EP-0564251-B1 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1995-09-06 EP disclosed
US-5397501-A Composition with surfactants for bleaching fabrics LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1995-03-14 US disclosed
WO-1995003275-A1 AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING UNILEVER N.V. (NL) 1995-02-02 WO disclosed
US-5268003-A Or salt thereof LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1993-12-07 US disclosed
EP-0564251-A2 Amido peroxycarboxylic acids UNILEVER PLC (GB) 1993-10-06 EP disclosed
EP-0564250-A2 Structured liquid detergent compositions containing amido and imido peroxy acids UNILEVER PLC (GB) 1993-10-06 EP disclosed
EP-0277376-B1 AROMATIC AMIDE GROUPS-CONTAINING DIAMINES AND POLYMERS IN WHICH THESE DIAMINES ARE INCORPORATED AKZO N.V. (NL) 1991-02-27 EP disclosed
US-4980444-A Polyamides, polyureas, polyimides; heat resistance, melt processability, high strength fibers, films AKZO N.V. (NL) 1990-12-25 US disclosed
US-4851562-A HEAT RESISTANCE, MELT PROCESS ABILITY AKZO N.V. (NL) 1989-07-25 US disclosed
US-4002600-A OR ISOPHTHALIC CID, A PROCESS FOR THEIR MANUFACTURE AND THEIR USEAMIDEOPHTHALIC ACID, A POROCESS FOR THE GROUPS CIBA-GEIGY CORPORATION (US) 1977-01-11 US disclosed