Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | PDE4A | P27815 | 7/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563196 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5563191 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5565644 | 0.88 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5565648 | 0.88 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5565643 | 0.88 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5567803 | 0.86 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5567804 | 0.86 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5567799 | 0.86 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL6453982 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL6453976 | 0.83 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163226-B1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2007-03-14 | — | — | EP | claimed |
| EP-1163226-B1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2007-03-14 | — | — | EP | disclosed |
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |
| EP-1163226-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000042018-A1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |