Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.41 |
| ▸ | PDE4A | P27815 | 12/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565648 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5565643 | 1.00 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5563196 | 0.88 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5563183 | 0.88 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5563191 | 0.88 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5036841 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CFYN | |
| SCHEMBL5036837 | 0.82 | PDE4D (0.53) | PDE4DPDE4APDE4BPDE4CFYN | |
| SCHEMBL5567799 | 0.78 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5567803 | 0.78 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3A | |
| SCHEMBL5567804 | 0.78 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163226-B1 | POLYSUBSTITUTED 6-PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2007-03-14 | — | — | EP | disclosed |
| US-6534518-B1 | Phosphodiesterase inhibitors for respiratory system disorders | ALTANA PHARMA AG (DE) | 2003-03-18 | — | — | US | disclosed |