Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.84 |
| ▸ | RAD52 | P43351 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156279 | 0.93 | MAPT (0.96) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL29507813 | 0.93 | MAPT (0.96) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL30600570 | 0.89 | MAPT (0.87) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL76629 | 0.84 | ALDH1A1 (0.96) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL15358686 | 0.84 | ALDH1A1 (0.81) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL5357582 | 0.84 | MAPT (0.73) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL160768 | 0.83 | ALDH1A1 (1.00) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL30336487 | 0.83 | ALDH1A1 (1.00) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL880495 | 0.83 | ALDH1A1 (0.59) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL13907868 | 0.82 | MAPT (0.57) | MAPTKDM4ERAD52ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748997-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005111013-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |
| US-20050256107-A1 | New substituted thiophene carboxamides, process for their preparation and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256107-A1 | New substituted thiophene carboxamides, process for their preparation and their use as medicaments | OTC, TPMT, ABCG2 | MAPT 1066/4885KDM4E 2298/4885RAD52 2499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.