Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563365 | 0.91 | KLK5 (0.38) | ACEKMT2ACTSKCTSSSCN9A | |
| SCHEMBL7653905 | 0.90 | SCN9A (0.43) | AGTR2ACEKMT2ACTSKCTSS | |
| SCHEMBL5569562 | 0.90 | AGTR2 (0.41) | AGTR2ACEKMT2ACTSKCTSS | |
| SCHEMBL5568420 | 0.90 | AGTR2 (0.41) | AGTR2ACEKMT2ACTSKCTSS | |
| SCHEMBL5568535 | 0.90 | SCN9A (0.43) | AGTR2ACEKMT2ACTSKCTSS | |
| SCHEMBL5563650 | 0.88 | AGTR2 (0.46) | AGTR2ACEKMT2ACTSKCTSS | |
| Trifluoroacetamide SCHEMBL8210272 | 0.85 | SCN9A (0.40) | AGTR2ACECTSKCTSSSCN9A | |
| 2,2,2-Trifluoroethanaminium SCHEMBL8210275 | 0.85 | SCN9A (0.41) | AGTR2ACECTSKCTSSSCN9A | |
| SCHEMBL5568411 | 0.85 | ACE (0.55) | ACE | |
| SCHEMBL5567555 | 0.84 | ACE (0.39) | AGTR2ACEKMT2ACTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042288-B1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2007-11-07 | — | — | EP | disclosed |
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |