Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 9/20 | 0.79 |
| ▸ | P2RX2 | Q9UBL9 | 9/20 | 0.79 |
| ▸ | CDK2 | P24941 | 11/20 | 0.52 |
| ▸ | CDK1 | P06493 | 10/20 | 0.52 |
| ▸ | CDK4 | P11802 | 10/20 | 0.52 |
| ▸ | CCND1 | P24385 | 10/20 | 0.52 |
| ▸ | CASK | O14936 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | CDK14 | O94921 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MAK | P20794 | 1/20 | 0.48 |
| ▸ | CDK11B | P21127 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CLK3 | P49761 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215772 | 0.88 | P2RX3 (0.81) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL2245909 | 0.88 | P2RX3 (0.81) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL30215859 | 0.88 | P2RX3 (0.81) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL1494073 | 0.88 | P2RX3 (0.81) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL13840773 | 0.86 | P2RX3 (0.78) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL5569085 | 0.85 | P2RX3 (0.77) | P2RX3P2RX2 | |
| SCHEMBL13842548 | 0.84 | P2RX3 (0.75) | P2RX3P2RX2CDK2CDK1CDK4 | |
| SCHEMBL1494018 | 0.80 | P2RX3 (0.70) | P2RX3P2RX2 | |
| SCHEMBL18084465 | 0.80 | P2RX3 (0.68) | P2RX3P2RX2CDK1 | |
| SCHEMBL19364011 | 0.79 | P2RX3 (0.73) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122859-A1 | METHODS OF USING DIAMINOPYRIMIDINE AS P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | ROCHE PALO ALTO LLC. | 2012-05-17 | — | — | US | disclosed |
| US-20110077242-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC | 2011-03-31 | — | — | US | disclosed |
| US-7858632-B2 | Purinergic receptor antagonists; genitourinary and pain-related diseases; for example, 5-(2-isopropyl-4,5-dimethoxybenzyl)-pyrimidine-2,4-diamine | ROCHE PALO ALTO LLC (US) | 2010-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077242-A1 | DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | P2RX3, P2RX6, P2RX2 | P2RX3 1/4885P2RX2 3/4885CDK2 1030/4885 |
| US-20120122859-A1 | METHODS OF USING DIAMINOPYRIMIDINE AS P2X3 AND P2X2/3 RECEPTOR MODULATORS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISEASES | P2RX3, P2RX2, P2RX6 | P2RX3 1/4885P2RX2 2/4885CDK2 2018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.