Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 7/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867721 | 0.77 | CLK1 (0.68) | BCL2L1CLK1DYRK1ADYRK1B | |
| SCHEMBL1230732 | 0.77 | CLK1 (0.50) | BCL2L1CLK1DYRK1ADYRK1BTBXAS1 | |
| SCHEMBL11100612 | 0.77 | KMT2A (0.64) | KMT2AMAPTTDP1MEN1CA2 | |
| SCHEMBL1639878 | 0.76 | KMT2A (1.00) | KMT2AMAPTTDP1MEN1CA12 | |
| SCHEMBL30523105 | 0.76 | KMT2A (1.00) | KMT2AMAPTTDP1MEN1CA12 | |
| SCHEMBL18058690 | 0.76 | KMT2A (0.93) | KMT2AMAPTTDP1MEN1CA12 | |
| SCHEMBL15697578 | 0.76 | DYRK1A (0.63) | KMT2ATDP1MEN1BCL2L1CLK1 | |
| SCHEMBL7214431 | 0.76 | C1S (0.70) | KMT2AMAPTTDP1MEN1CA2 | |
| Benzoic Acid SCHEMBL9956914 | 0.75 | KMT2A (0.90) | KMT2AMAPTTDP1MEN1CA12 | |
| SCHEMBL10778099 | 0.75 | KMT2A (0.77) | KMT2AMAPTTDP1MEN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208491-B2 | N-monoacylated o-phenylenediamines | HOFFMANN-LA ROCHE INC. (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |
| US-20040157841-A1 | inhibition of histone deacetylase; for inhibiting cell proliferation; cancer therapy | HOFFMANN-LA ROCHE INC. | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157841-A1 | inhibition of histone deacetylase; for inhibiting cell proliferation; cancer therapy | HDAC1, HDAC11, HDAC7 | KMT2A 55/4885MAPT 3808/4885TDP1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.