Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.79 |
| ▸ | RET | P07949 | 4/20 | 0.79 |
| ▸ | KIF5B | P33176 | 2/20 | 0.79 |
| ▸ | EGFR | P00533 | 17/20 | 0.78 |
| ▸ | CLK1 | P49759 | 1/20 | 0.78 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.78 |
| ▸ | LCK | P06239 | 5/20 | 0.76 |
| ▸ | FLT1 | P17948 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.70 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.70 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.70 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.70 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.70 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865262 | 0.88 | EGFR (0.81) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL5651286 | 0.88 | KDR (1.00) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL6783334 | 0.88 | KDR (0.74) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL6068633 | 0.88 | KDR (0.82) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL5565137 | 0.87 | EGFR (1.00) | KDRRETKIF5BEGFRCLK1 | |
| Hydrochloric Acid SCHEMBL7859467 | 0.87 | KDR (0.98) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL14979614 | 0.87 | EGFR (0.71) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL5473778 | 0.86 | EGFR (0.80) | KDRRETKIF5BEGFRCLK1 | |
| Hydrochloric Acid SCHEMBL5473795 | 0.85 | EGFR (0.80) | KDRRETKIF5BEGFRCLK1 | |
| SCHEMBL5473780 | 0.85 | EGFR (0.78) | KDRRETKIF5BEGFRCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123537-A1 | Quinazoline derivatives for the treatment of herpesviral infections | GPC BIOTECH AG (DE) | 2007-05-31 | — | — | US | claimed |
| EP-1673346-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS | GPC Biotech AG (DE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005040125-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS | GPC BIOTECH AG (DE) | 2005-05-06 | — | — | WO | claimed |
| US-9353116-B2 | Methods and compositions for kinase inhibition | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-05-31 | — | — | US | disclosed |
| US-20130137708-A1 | METHODS AND COMPOSITIONS FOR KINASE INHIBITION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-30 | — | — | US | disclosed |
| US-20070123537-A1 | Quinazoline derivatives for the treatment of herpesviral infections | GPC BIOTECH AG (DE) | 2007-05-31 | — | — | US | disclosed |
| EP-1673346-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS | GPC Biotech AG (DE) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040125-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF HERPESVIRAL INFECTIONS | GPC BIOTECH AG (DE) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137708-A1 | METHODS AND COMPOSITIONS FOR KINASE INHIBITION | SRC, ABL1, LCK | KDR 1851/4885RET 120/4885KIF5B 1176/4885 |
| US-20070123537-A1 | Quinazoline derivatives for the treatment of herpesviral infections | IRF3, PML, TPMT | KDR 2712/4885RET 2776/4885KIF5B 2469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.