Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.80 |
| ▸ | KDR | P35968 | 9/20 | 0.80 |
| ▸ | LCK | P06239 | 5/20 | 0.80 |
| ▸ | RET | P07949 | 4/20 | 0.78 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.78 |
| ▸ | FLT1 | P17948 | 1/20 | 0.78 |
| ▸ | GAK | O14976 | 1/20 | 0.78 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | FLT3 | P36888 | 1/20 | 0.78 |
| ▸ | JAK3 | P52333 | 1/20 | 0.78 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.78 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.78 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.78 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.78 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.78 |
| ▸ | CLK1 | P49759 | 1/20 | 0.77 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.77 |
| ▸ | KIF5B | P33176 | 2/20 | 0.70 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5473795 | 0.99 | EGFR (0.80) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL14159636 | 0.91 | KDR (0.73) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL31067650 | 0.90 | KDR (0.83) | EGFRKDR | |
| SCHEMBL5467825 | 0.89 | EGFR (1.00) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL3533221 | 0.89 | EGFR (0.80) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL5472599 | 0.89 | EGFR (1.00) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL5477771 | 0.87 | KDR (1.00) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL1387182 | 0.87 | EGFR (0.94) | EGFRKDRLCKRETRIPK2 | |
| Whi-P131 SCHEMBL29295 | 0.87 | EGFR (1.00) | EGFRKDRLCKRETRIPK2 | |
| SCHEMBL5473780 | 0.87 | EGFR (0.78) | EGFRKDRLCKRETRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852128-A | Quinazoline derivative containing 2-indolone as well as preparation method and application thereof | 成都安博力善生物科技有限公司 | 2024-10-29 | — | — | CN | disclosed |
| US-11806555-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-11-07 | — | — | US | disclosed |
| US-9895301-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-20 | — | — | US | disclosed |
| US-9763866-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-09-19 | — | — | US | disclosed |
| US-9737469-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-22 | — | — | US | disclosed |
| US-9730877-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160256374-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160256461-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160058764-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160058765-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-03-03 | — | — | US | disclosed |
| US-9198911-B2 | Methods for treating hair loss disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-12-01 | — | — | US | disclosed |
| US-20140065153-A1 | Methods for Treating Hair Loss Disorders | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-03-06 | — | — | US | disclosed |
| US-8513267-B2 | 4-anilinoquinazoline derivatives with adenosine-kinase inhibitor properties | UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP (BR) | 2013-08-20 | — | — | US | disclosed |
| EP-1737832-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES WITH ADENOSINE-KINASE INHIBITORY PROPERTIES | UNICAMP (BR) | 2011-12-14 | — | — | EP | disclosed |
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20070060600-A1 | 4-Anilinequinazolines with adenosine-kiase inhibitor properties | UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP (BR) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11806555-B2 | Methods for treating hair loss disorders | PRKACB, PRKACA, PRKACG | EGFR 625/4885KDR 3903/4885LCK 112/4885 |
| US-20160058765-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | PRKACB, PRKACA, PRKACG | EGFR 625/4885KDR 3903/4885LCK 112/4885 |
| US-20160256461-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | PRKACB, PRKACA, PRKACG | EGFR 625/4885KDR 3903/4885LCK 112/4885 |
| US-20160256374-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | PRKACB, PRKACA, PRKACG | EGFR 625/4885KDR 3903/4885LCK 112/4885 |
| US-20160058764-A1 | METHODS FOR TREATING HAIR LOSS DISORDERS | PRKACB, PRKACA, PRKACG | EGFR 625/4885KDR 3903/4885LCK 112/4885 |
| US-20070060600-A1 | 4-Anilinequinazolines with adenosine-kiase inhibitor properties | ADK, AK1, ADORA3 | EGFR 3142/4885KDR 1289/4885LCK 860/4885 |
| US-20140065153-A1 | Methods for Treating Hair Loss Disorders | JAK3, JAK2, JAK1 | EGFR 549/4885KDR 4166/4885LCK 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.