Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14407231 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10761454 | 0.86 | KDM4E (0.44) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL14407214 | 0.86 | KDM4E (0.44) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5565447 | 0.85 | KDM4E (0.44) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29079914 | 0.83 | EPHX2 (0.36) | ALDH1A1KDM4EMAPK1HSD17B10MEN1 | |
| SCHEMBL27693530 | 0.82 | MAPT (0.45) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30562957 | 0.79 | GAA (0.59) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10334541 | 0.79 | GAA (0.59) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL3182006 | 0.79 | GAA (0.59) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30104029 | 0.79 | GAA (0.59) | ALDH1A1KDM4ECYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042288-B1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2007-11-07 | — | — | EP | disclosed |
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |