Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 8/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566113 | 1.00 | ADRB3 (0.41) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5034327 | 0.95 | ADRB2 (0.47) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5034329 | 0.95 | ADRB2 (0.47) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL14204699 | 0.94 | ADRB3 (0.40) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5034398 | 0.92 | ADRB3 (0.41) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5034395 | 0.92 | ADRB3 (0.41) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL14204685 | 0.89 | ADRB2 (0.46) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5037084 | 0.88 | ADRB2 (0.42) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5037087 | 0.88 | ADRB2 (0.42) | ADRB3ADRB2ADRA1DADRA1AADRA1B | |
| SCHEMBL5563548 | 0.88 | ADRB2 (0.47) | ADRB3ADRB2TRPV1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708992-B1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LTD (GB) | 2007-08-08 | — | — | EP | disclosed |
| EP-1708992-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005080324-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |