Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570186 | 0.91 | SYK (0.51) | SYKKARS1 | |
| Hydrochloric Acid SCHEMBL5570303 | 0.88 | HRH3 (0.41) | SYKEGFRJAK2CDK2TYK2 | |
| SCHEMBL2869684 | 0.86 | SYK (0.52) | SYKCDK2KDR | |
| SCHEMBL2870223 | 0.85 | SYK (0.52) | SYKEGFRKARS1 | |
| SCHEMBL2868310 | 0.84 | SYK (0.53) | SYK | |
| Hydrochloric Acid SCHEMBL2863199 | 0.83 | SYK (0.52) | SYK | |
| SCHEMBL2866302 | 0.83 | SYK (0.50) | SYKEGFRJAK2TYK2KARS1 | |
| SCHEMBL2866305 | 0.83 | SYK (0.50) | SYKEGFRJAK2TYK2KARS1 | |
| SCHEMBL5570473 | 0.81 | SYK (0.49) | SYKKARS1 | |
| SCHEMBL2870099 | 0.80 | SYK (0.48) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1854793-A1 | NOVEL AMINOPYRIDINE COMPOUND WITH Syk INHIBITORY ACTIVITY | Japan Tobacco, Inc. (JP) | 2007-11-14 | — | — | EP | claimed |