Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568081 | 0.88 | MAP2K1 (0.42) | MAP2K1ACP1ROCK1ROCK2KCNH2 | |
| SCHEMBL5568804 | 0.82 | MAP2K1 (0.42) | MAP2K1PLA2G2AACP1ROCK2IRAK4 | |
| SCHEMBL4505136 | 0.80 | HRH3 (0.48) | — | |
| SCHEMBL5566839 | 0.76 | MAP2K1 (0.42) | MAP2K1ACP1CHEK2IRAK4PARP10 | |
| SCHEMBL5563904 | 0.76 | MAP2K1 (0.44) | MAP2K1ACP1CHEK2IRAK4PARP10 | |
| SCHEMBL5561694 | 0.74 | IRAK4 (0.43) | MAP2K1ACP1CHEK2IRAK4 | |
| SCHEMBL5562276 | 0.73 | ACP1 (0.41) | MAP2K1ACP1 | |
| SCHEMBL5562248 | 0.72 | ACP1 (0.39) | MAP2K1ACP1IRAK4PARP10PARP15 | |
| SCHEMBL5561686 | 0.71 | KMT2A (0.47) | MAP2K1ACP1CHEK2 | |
| SCHEMBL5562096 | 0.71 | ACP1 (0.50) | MAP2K1ACP1ROCK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755593-A1 | NAPHTHALINE DERIVATIVES USEFUL AS HISTAMINE-3-RECEPTOR LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005117865-A1 | NAPHTHALINE DERIVATIVES USEFUL AS HISTAMINE-3-RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |