Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 7/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566839 | 0.87 | MAP2K1 (0.42) | ACP1MAP2K1MAOABCHEACHE | |
| SCHEMBL5561694 | 0.80 | IRAK4 (0.43) | ACP1MAP2K1IRAK4PDPK1RPS6KB1 | |
| SCHEMBL5563904 | 0.79 | MAP2K1 (0.44) | ACP1MAP2K1IRAK4GRK2PDPK1 | |
| SCHEMBL4505175 | 0.79 | HRH3 (0.50) | MAOB | |
| SCHEMBL5568804 | 0.77 | MAP2K1 (0.42) | ACP1MAP2K1IRAK4GRK2PDPK1 | |
| SCHEMBL5562276 | 0.76 | ACP1 (0.41) | ACP1MAP2K1MAOABCHEACHE | |
| SCHEMBL5568081 | 0.75 | MAP2K1 (0.42) | ACP1MAP2K1IRAK4GRK2PDPK1 | |
| SCHEMBL5178131 | 0.75 | ACP1 (0.46) | ACP1MAP2K1MAOABCHEACHE | |
| SCHEMBL5562096 | 0.73 | ACP1 (0.50) | ACP1MAP2K1 | |
| SCHEMBL5566907 | 0.72 | MAP2K1 (0.41) | ACP1MAP2K1IRAK4PARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755593-A1 | NAPHTHALINE DERIVATIVES USEFUL AS HISTAMINE-3-RECEPTOR LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005117865-A1 | NAPHTHALINE DERIVATIVES USEFUL AS HISTAMINE-3-RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |