Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021701 | 0.84 | NPC1 (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL5566573 | 0.79 | TDP1 (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL14016423 | 0.78 | NPC1 (0.41) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL13910159 | 0.77 | RAB9A (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL10330351 | 0.77 | RAB9A (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL27491338 | 0.76 | HRH3 (0.48) | KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19075474 | 0.75 | GAA (0.41) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL13910153 | 0.75 | MAOB (0.47) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL21336168 | 0.72 | NPC1 (0.37) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL21336154 | 0.68 | NPC1 (0.42) | KDM4EALDH1A1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190698-A1 | ENZYME INTERACTING AGENTS | CENTRAL ADELAIDE LOCAL HEALTH NETWORK INCORPORATED (AU) | 2017-07-06 | — | — | US | disclosed |
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190698-A1 | ENZYME INTERACTING AGENTS | SMPD1, SMPD2, ASAH1 | KDM4E 3234/4885ALDH1A1 1318/4885SMN1; SMN2 3115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.