Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753958 | 0.85 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL13652961 | 0.84 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL4822025 | 0.84 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7908615 | 0.83 | PDE4A (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7341124 | 0.83 | PDE4A (0.78) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5610531 | 0.83 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7180229 | 0.83 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6906296 | 0.83 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL477320 | 0.82 | CNR2 (0.58) | — | |
| SCHEMBL7317788 | 0.82 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819123-B1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-12-12 | — | — | EP | disclosed |
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| EP-0626939-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2001-11-07 | — | — | EP | disclosed |
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| US-6153630-A | Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same | EURO-CELTIQUE, S.A. (LU) | 2000-11-28 | — | — | US | disclosed |
| US-5952510-A | ENZYME INHIBITOR AS ANTIALLERGENS, ANTIINFLAMMATORY AGENT TREATING INFLAMMATION DISEASES, SKIN DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BG) | 1999-09-14 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5889014-A | ASTHMA, ARTHRITIS, ALLERGIES, INFLAMMATION, DEPRESSION THERAPY | EURO-CELTIQUE, S.A. (LU) | 1999-03-30 | — | — | US | disclosed |
| EP-0626957-B1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 1999-03-03 | — | — | EP | disclosed |
| EP-0819123-A1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-01-21 | — | — | EP | disclosed |
| US-5622977-A | ANTIINFLAMMATORY AGENT, ANTIALLERGENS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-22 | — | — | US | disclosed |
| US-5591776-A | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV | EURO-CELTIQUE, S.A. (LU) | 1997-01-07 | — | — | US | disclosed |
| US-5580888-A | Styryl derivatives as anti-inflammatory agents | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| WO-1996031486-A1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-10 | — | — | WO | disclosed |
| EP-0626957-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| EP-0626939-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014800-A1 | STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994014742-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |