Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567417 | 0.83 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL12180739 | 0.79 | PDE4A (0.55) | PDE4AHIF1ARECQLPDE4DPDE4B | |
| SCHEMBL29340248 | 0.78 | NPY1R (0.49) | PDE4ARECQLPDE4DPDE4BPDE4C | |
| SCHEMBL6896766 | 0.76 | CYP1A2 (0.54) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5610531 | 0.76 | PDE4A (0.59) | PDE4AHIF1APDE4DPDE4BPDE4C | |
| SCHEMBL6902254 | 0.76 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL129356 | 0.75 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4CLMNA | |
| SCHEMBL22420280 | 0.74 | HIF1A (0.47) | PDE4AHIF1ARECQLPDE4DPDE4B | |
| SCHEMBL5704271 | 0.74 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7175088 | 0.74 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202955-A4 | 1,4-SUBSTITUTED 4,4-DIARYL CYCLOHEXANES | SMITHKLINE BEECHAM CORP (US) | 2004-02-11 | — | — | EP | disclosed |
| US-6518306-B1 | PDE4 inhibitors particularly in regards to treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1202955-A2 | 1,4-SUBSTITUTED 4,4-DIARYL CYCLOHEXANES | SmithKline Beecham Corporation (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010385-A2 | 1,4-SUBSTITUTED 4,4-DIARYL CYCLOHEXANES | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-15 | — | — | WO | disclosed |