Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23345002 | 0.82 | CYP2D6 (0.44) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL18049865 | 0.79 | CYP2D6 (0.46) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL14417823 | 0.78 | CYP2D6 (0.44) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL3782563 | 0.74 | CYP2D6 (0.44) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL17501169 | 0.72 | CYP2D6 (0.43) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL13594764 | 0.72 | CYP2D6 (0.46) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL7396980 | 0.72 | CYP1A2 (0.32) | CYP1A2 | |
| SCHEMBL20847066 | 0.71 | CYP2D6 (0.39) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL17970231 | 0.70 | ALDH1A1 (0.44) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 | |
| SCHEMBL23995668 | 0.69 | CYP2D6 (0.41) | CYP2D6SMN1; SMN2CYP2C19NEK2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |
| CN-1312127-C | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMA CO LTD (JP) | 2007-04-25 | — | — | CN | disclosed |
| CN-1665785-A | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMA CO LTD (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-20050176771-A1 | 2-Cyano-4-fluoropyrrolidine derivative or its salt | ASTELLAS PHARMA INC. (JP) | 2005-08-11 | — | — | US | disclosed |
| EP-1541551-A1 | 2-CYANO-4-FLUOROPYRROLIDINE DERIVATIVE OR ITS SALT | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176771-A1 | 2-Cyano-4-fluoropyrrolidine derivative or its salt | DPP4, DPP7, DPP9 | CYP2D6 3089/4885SMN1; SMN2 2483/4885CYP2C19 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.