Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 7/20 | 0.58 |
| ▸ | HTR2C | P28335 | 7/20 | 0.58 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 5/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565177 | 0.87 | SRC (0.69) | SRCMCHR1HTR2AHTR2CBRAF | |
| SCHEMBL5569333 | 0.86 | MCHR1 (0.63) | MCHR1HTR2AHTR2CLTA4HKDR | |
| SCHEMBL5569396 | 0.86 | MCHR1 (0.66) | SRCMCHR1HTR2AHTR2CLTA4H | |
| SCHEMBL5565308 | 0.84 | LTA4H (0.74) | MCHR1LTA4HHRH3 | |
| SCHEMBL3166510 | 0.83 | KDR (0.60) | SRCHTR2AHTR2CBRAFMAPK14 | |
| SCHEMBL5568243 | 0.79 | KDR (0.58) | SRCHTR2AHTR2CBRAFMAPK14 | |
| SCHEMBL3185956 | 0.79 | SRC (0.60) | SRCHTR2AHTR2CBRAFMAPK14 | |
| SCHEMBL19911109 | 0.77 | SRC (1.00) | SRCBRAFMAPK14KDRTNNI3K | |
| SCHEMBL16990649 | 0.75 | FLT1 (0.49) | SRCHTR2ABRAFMAPK14LTA4H | |
| SCHEMBL14453610 | 0.75 | RAF1 (0.73) | SRCMCHR1HTR2AHTR2CBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007519653-A | — | — | 2007-07-19 | — | — | JP | claimed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | claimed |
| EP-1730111-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005075425-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-08-18 | — | — | WO | claimed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| EP-1730111-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005075425-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | BRAF, RAF1, NRAS | SRC 385/4885MCHR1 4656/4885HTR2A 4603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.