Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571876 | 0.81 | HRH3 (0.43) | SMN1; SMN2ALDH1A1HRH3 | |
| SCHEMBL550469 | 0.77 | HRH3 (0.44) | SMN1; SMN2ALDH1A1KMT2AMEN1HRH3 | |
| SCHEMBL550240 | 0.75 | KDM4E (0.50) | CRBNALDH1A1POLBHRH3 | |
| SCHEMBL550640 | 0.73 | KCNH2 (0.43) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL550639 | 0.73 | KCNH2 (0.43) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL550795 | 0.72 | HRH3 (0.46) | SMN1; SMN2ALDH1A1POLBHRH3 | |
| SCHEMBL550896 | 0.71 | AKR1C3 (0.46) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL550389 | 0.70 | DDB1 (0.49) | CRBNSMN1; SMN2ALDH1A1POLBHRH3 | |
| SCHEMBL550388 | 0.70 | DDB1 (0.49) | CRBNSMN1; SMN2ALDH1A1POLBHRH3 | |
| SCHEMBL550908 | 0.70 | HSD11B1 (0.40) | ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |