Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1487384 | 1.00 | MEN1 (0.38) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL1487329 | 1.00 | MEN1 (0.38) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL1487412 | 0.84 | CHRM4 (0.32) | — | |
| SCHEMBL23573267 | 0.84 | TP53 (0.50) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL23573353 | 0.84 | TP53 (0.50) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL15017224 | 0.84 | TP53 (0.50) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL17591906 | 0.77 | MEN1 (0.43) | MEN1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL3587515 | 0.76 | CTSK (0.58) | CYP2C9 | |
| SCHEMBL1714125 | 0.76 | MEN1 (0.64) | MEN1KMT2AALDH1A1LMNAEPHX2 | |
| SCHEMBL28010843 | 0.76 | CTSK (0.58) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809624-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006024823-A9 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-03-15 | — | — | WO | disclosed |
| WO-2006024823-A1 | PYRIMIDINE SULPHONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | WO | disclosed |