⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323289 | 1.00 | — | — | |
| SCHEMBL16139775 | 1.00 | — | — | |
| SCHEMBL3344986 | 0.80 | — | — | |
| SCHEMBL21254131 | 0.80 | — | — | |
| SCHEMBL14827808 | 0.80 | — | — | |
| SCHEMBL16118869 | 0.79 | — | — | |
| SCHEMBL437804 | 0.79 | — | — | |
| SCHEMBL761123 | 0.79 | — | — | |
| SCHEMBL14749839 | 0.79 | — | — | |
| SCHEMBL16892255 | 0.78 | KMT2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819693-A1 | ANTITHROMBOTIC DIAMIDES | ELI LILLY AND COMPANY (US) | 2007-08-22 | — | — | EP | claimed |
| WO-2006057868-A1 | ANTITHROMBOTIC DIAMIDES | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | claimed |
| EP-2970224-B1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-9701631-B2 | TIP60 inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160368946-A1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2016-12-22 | — | — | US | disclosed |
| US-9434761-B2 | Tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-09-06 | — | — | US | disclosed |
| US-20140187579-A1 | TIP60 INHIBITORS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-07-03 | — | — | US | disclosed |
| US-8497285-B2 | Therapy of autoimmune colitis using a TIP60 inhibitor | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-07-30 | — | — | US | disclosed |
| US-20120202848-A1 | THERAPY OF AUTOIMMUNE COLITIS USING A TIP60 INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-08-09 | — | — | US | disclosed |
| EP-2275412-A1 | Indole and benzimidazole derivatives | Novartis Vaccines and Diagnostics, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-1819693-A1 | ANTITHROMBOTIC DIAMIDES | ELI LILLY AND COMPANY (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006057868-A1 | ANTITHROMBOTIC DIAMIDES | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
| US-6872827-B2 | Somatostatin analogue compounds | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2005-03-29 | — | — | US | disclosed |