SCHEMBL5568646

SCHEMBL5568646

CC[C@H](NC(=O)OC(C)(C)C)C(=O)N1c2ccc(OC)cc2C[C@@H]1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 7/20 0.42
HDAC3 O15379 2/20 0.42
HDAC4 P56524 2/20 0.42
HDAC1 Q13547 2/20 0.42
HDAC7 Q8WUI4 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC10 Q969S8 2/20 0.42
HDAC11 Q96DB2 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC9 Q9UKV0 2/20 0.42
HDAC5 Q9UQL6 2/20 0.42
MMP2 P08253 2/20 0.41
MMP9 P14780 2/20 0.41
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5566971 1.00 HDAC8 (0.42) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL5564518 0.92 HDAC8 (0.42) HDAC8HDAC3HDAC4HDAC1HDAC7
SCHEMBL5568442 0.90 SCN9A (0.37)
SCHEMBL5563792 0.90 SCN9A (0.37)
SCHEMBL5568361 0.88 ACE (0.40)
SCHEMBL5568606 0.87 HDAC8 (0.44) HDAC8PPARA
SCHEMBL5563160 0.87 HDAC8 (0.44) HDAC8PPARA
SCHEMBL7668349 0.87 MC4R (0.42) ALDH1A1PPARGPPARA
SCHEMBL5563362 0.87 MC4R (0.42) ALDH1A1PPARGPPARA
Trifluoroacetamide SCHEMBL8207815 0.86 SCN9A (0.35) HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042288-B1 TRIPEPTIDYL PEPTIDASE INHIBITORS INST NAT SANTE RECH MED (FR) 2007-11-07 EP disclosed
US-6335360-B1 INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2002-01-01 US disclosed
EP-1042288-A1 TRIPEPTIDYL PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2000-10-11 EP disclosed
WO-1999033801-A1 TRIPEPTIDYL PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1999-07-08 WO disclosed