Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CCR9 | P51686 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307420 | 0.89 | CYP2C9 (0.53) | CCR2CYP3A4 | |
| SCHEMBL130229 | 0.82 | CCR2 (0.53) | CCR2TSHRCYP3A4CCR9ALDH1A1 | |
| SCHEMBL170277 | 0.81 | CCR2 (0.60) | CCR2TSHRCYP3A4CCR9ALDH1A1 | |
| SCHEMBL305651 | 0.80 | CYP2C9 (0.55) | CCR2TSHRCYP3A4ALDH1A1LMNA | |
| SCHEMBL15259955 | 0.78 | CCR2 (0.58) | CCR2TSHRCYP3A4CCR9ALDH1A1 | |
| SCHEMBL12594839 | 0.77 | CCR2 (0.45) | CCR2CYP3A4CCR9LMNA | |
| SCHEMBL305303 | 0.76 | CYP2C9 (0.54) | CCR2CYP3A4 | |
| SCHEMBL130228 | 0.76 | CCR2 (0.52) | CCR2TSHRCYP3A4ALDH1A1LMNA | |
| SCHEMBL305740 | 0.75 | TSHR (0.55) | CCR2TSHRCYP3A4CCR9 | |
| SCHEMBL306635 | 0.75 | CYP2C9 (0.54) | CCR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |