Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.69 |
| ▸ | RAF1 | P04049 | 6/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | FRK | P42685 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565301 | 0.92 | MAPK14 (0.66) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5564591 | 0.90 | MCHR1 (0.67) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5621111 | 0.89 | HRH3 (0.60) | MAPK14RAF1HRH3MCHR1LTA4H | |
| SCHEMBL5621809 | 0.89 | MCHR1 (0.61) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5565177 | 0.87 | SRC (0.69) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5569051 | 0.87 | MAPK14 (0.59) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5569106 | 0.87 | MAPK14 (0.63) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL5569661 | 0.86 | GSK3B (0.60) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL14453662 | 0.85 | MAPK14 (0.59) | MAPK14RAF1EPHX2SRCKDR | |
| SCHEMBL14453610 | 0.85 | RAF1 (0.73) | MAPK14RAF1EPHX2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | claimed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| EP-1730111-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005075425-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | BRAF, RAF1, NRAS | MAPK14 233/4885RAF1 2/4885EPHX2 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.