Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622122 | 0.91 | MAPK14 (0.52) | HRH3MCHR1MAPK14RAF1 | |
| SCHEMBL5568993 | 0.89 | MAPK14 (0.69) | HRH3MCHR1MAPK14LTA4HRAF1 | |
| SCHEMBL5565308 | 0.86 | LTA4H (0.74) | HRH3MCHR1LTA4HKCNH2 | |
| SCHEMBL5565301 | 0.81 | MAPK14 (0.66) | MAPK14RAF1 | |
| SCHEMBL5620472 | 0.80 | HRH3 (0.59) | HRH3MAPK14LTA4HRAF1 | |
| SCHEMBL5564591 | 0.79 | MCHR1 (0.67) | MCHR1MAPK14MCHR2RAF1 | |
| SCHEMBL5621809 | 0.79 | MCHR1 (0.61) | MCHR1MAPK14RAF1 | |
| SCHEMBL5569051 | 0.77 | MAPK14 (0.59) | HRH3MCHR1MAPK14RAF1 | |
| SCHEMBL5565177 | 0.77 | SRC (0.69) | MCHR1MAPK14RAF1 | |
| SCHEMBL5569106 | 0.77 | MAPK14 (0.63) | MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007519653-A | — | — | 2007-07-19 | — | — | JP | claimed |
| EP-1730111-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005075425-A2 | SUBSTITUTED BISARYLUREA DERIVATIVES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-08-18 | — | — | WO | claimed |