Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956111 | 0.76 | HCAR2 (0.68) | HCAR2KDM4EPOLBPDE4DHCAR3 | |
| SCHEMBL4876540 | 0.74 | KDM4E (0.44) | HCAR2KDM4EPOLBPDE4DHCAR3 | |
| SCHEMBL3389520 | 0.70 | KDM4E (0.43) | HCAR2KDM4EPOLBPDE4DMAPT | |
| SCHEMBL2869702 | 0.70 | KDM4E (0.46) | HCAR2KDM4EPOLBPDE4DMAPT | |
| SCHEMBL23112395 | 0.69 | KDM4E (0.48) | KDM4EPOLBPDE4DMAPTKMT2A | |
| SCHEMBL9025212 | 0.68 | HCAR2 (0.66) | HCAR2KDM4EPOLBPDE4DMAPT | |
| SCHEMBL5763853 | 0.68 | KDM4E (0.47) | KDM4EPOLBPDE4DMAPTKMT2A | |
| SCHEMBL24235249 | 0.67 | KDM4E (0.46) | KDM4EPOLBPDE4DMAPTKMT2A | |
| SCHEMBL5572083 | 0.67 | HCAR2 (0.43) | HCAR2KDM4EPOLBPDE4DMAPT | |
| SCHEMBL7814443 | 0.66 | PDE4D (0.58) | HCAR2KDM4EPOLBPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |