Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568377 | 0.83 | HCAR2 (0.41) | HCAR2KDM4EPOLBPDE4DLMNA | |
| SCHEMBL9025212 | 0.80 | HCAR2 (0.66) | HCAR2KDM4EPOLBPDE4DALDH1A1 | |
| SCHEMBL19158730 | 0.73 | PDE4D (0.59) | HCAR2KDM4EPOLBPDE4DALDH1A1 | |
| SCHEMBL3956111 | 0.72 | HCAR2 (0.68) | HCAR2KDM4EPOLBPDE4DMAPT | |
| SCHEMBL12076498 | 0.72 | KDM4E (0.49) | HCAR2KDM4EPOLBPDE4DLMNA | |
| SCHEMBL2869702 | 0.72 | KDM4E (0.46) | HCAR2KDM4EPOLBPDE4DALDH1A1 | |
| SCHEMBL15555140 | 0.72 | KDM4E (0.51) | HCAR2KDM4EPOLBPDE4DLMNA | |
| SCHEMBL10860621 | 0.72 | KDM4E (0.51) | KDM4EPOLBPDE4DLMNAALDH1A1 | |
| SCHEMBL10862602 | 0.72 | KDM4E (0.51) | HCAR2KDM4EPOLBPDE4DALDH1A1 | |
| SCHEMBL28835650 | 0.71 | HCAR2 (0.49) | HCAR2KDM4EPOLBPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |