Bromomethane

Bromomethane

SCHEMBL5569428

CBr.CCNOC(c1ccccc1)c1ccccc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.47
SLC6A4 P31645 5/20 0.40
LMNA P02545 5/20 0.39
SCN1A P35498 3/20 0.39
SCN2A Q99250 3/20 0.39
SCN3A Q9NY46 3/20 0.39
CHRM2 P08172 3/20 0.39
ADRA2A P08913 3/20 0.39
CHRM1 P11229 3/20 0.39
SLC6A2 P23975 3/20 0.39
OPRM1 P35372 3/20 0.39
DRD3 P35462 3/20 0.39
SLC6A3 Q01959 3/20 0.39
HRH1 P35367 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
ADRA1A P35348 2/20 0.39
HTR2B P41595 2/20 0.39
KCNH2 Q12809 2/20 0.39
CHRM4 P08173 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9291837 0.96 HTT (0.50) HTTSLC6A4LMNASCN1ASCN2A
SCHEMBL5160308 0.81 SLC6A4 (0.51) HTTSLC6A4LMNACHRM2ADRA2A
SCHEMBL11597642 0.80 HTT (0.47) HTTSLC6A4LMNASCN1ASCN2A
Formamide SCHEMBL5161694 0.76 MEN1 (0.46) HTTSLC6A4LMNACHRM2ADRA2A
SCHEMBL27985641 0.72 HRH1 (0.48) HTTSLC6A4SLC6A3HRH1CYP1A2
SCHEMBL4460543 0.72 TAAR1 (0.45) HTTSLC6A4LMNASCN1ASCN2A
SCHEMBL7299603 0.69 LMNA (0.43) HTTSLC6A4LMNASCN1ASCN2A
SCHEMBL16889007 0.68 HTT (0.41) HTTSLC6A4LMNASCN1ASCN2A
SCHEMBL9467177 0.67 IDO1 (0.42) HTTSLC6A4LMNASCN1ASCN2A
SCHEMBL3992907 0.67 SCN1A (0.55) HTTSLC6A4LMNASCN1ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680121-A4 METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS COMBINATORX INC (US) 2007-12-26 EP disclosed
EP-1680121-A2 METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS CombinatoRx, Incorporated (US) 2006-07-19 EP disclosed
EP-1599212-A4 COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS COMBINATORX INC (US) 2006-02-08 EP disclosed
EP-1599212-A2 COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS Combinatorx, Incorporated (US) 2005-11-30 EP disclosed
WO-2005037203-A2 METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS COMBINATORX, INCORPORATED (US) 2005-04-28 WO disclosed
WO-2004073614-A2 COMBINATION THERAPY FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS COMBINATORX, INCORPORATED (US) 2004-09-02 WO disclosed