SCHEMBL5569508

SCHEMBL5569508

COc1cc(-c2ccc(C(=O)N3CCN(Cc4cccc(CN5CCN(C(=O)c6ccc(-c7cc(OC)c(OC)c(OC)c7)cc6)CC5)n4)CC3)cc2)cc(OC)c1OC

nearest known ligand 0.66

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.66
ALDH1A1 P00352 10/20 0.59
KDM4E B2RXH2 6/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
HTT P42858 2/20 0.59
LMNA P02545 3/20 0.54
MAPT P10636 2/20 0.54
RECQL P46063 1/20 0.54
CYP1A2 P05177 1/20 0.54
TSHR P16473 1/20 0.54
MAPK1 P28482 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.53
GAA P10253 1/20 0.53
LSS P48449 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5572688 0.99 POLB (0.65) POLBALDH1A1KDM4EMEN1KMT2A
SCHEMBL5572636 0.85 POLB (0.76) POLBALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL5572656 0.84 POLB (0.74) POLBALDH1A1KDM4EMEN1KMT2A
SCHEMBL5569613 0.84 POLB (0.67) POLBALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL5569620 0.83 POLB (0.65) POLBALDH1A1KDM4EMEN1KMT2A
SCHEMBL5572651 0.82 POLB (0.64) POLBALDH1A1KDM4EMEN1KMT2A
SCHEMBL5572627 0.82 POLB (0.64) POLBALDH1A1KDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL5570686 0.81 POLB (0.63) POLBALDH1A1KDM4EMEN1KMT2A
SCHEMBL6785344 0.80 ALDH1A1 (0.67) POLBALDH1A1MEN1KMT2AHTT
Hydrochloric Acid SCHEMBL7030279 0.80 POLB (0.62) POLBALDH1A1KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1057815-B1 CYCLIC AMIDE COMPOUNDS KOWA CO (JP) 2007-09-05 EP disclosed
US-6645957-B2 Useful in preventing and treating allergic immunological diseases; treating asthma, atopic dermatitis, allergic rhinitis, inflammatory large bowel disease, contact dermatitis KOWA CO., LTD. (JP) 2003-11-11 US disclosed
US-20030096828-A1 Cyclic amide compound KOWA CO., LTD. (JP) 2003-05-22 US disclosed
US-6448242-B1 COMPOUND HAVING A STRONG INHIBITORY EFFECT ON THE PRODUCTION OF AN IGE ANTIBODY; ANTIALLERGENS KOWA CO., LTD. (JP) 2002-09-10 US disclosed
EP-1057815-A1 CYCLIC AMIDE COMPOUNDS Kowa Co., Ltd. (JP) 2000-12-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030096828-A1 Cyclic amide compound CMA1, HRH2, HRH4 POLB 3136/4885ALDH1A1 2028/4885KDM4E 218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.