Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565611 | 0.92 | ACE (0.62) | ACE | |
| SCHEMBL7044444 | 0.89 | ACE (0.53) | ACE | |
| SCHEMBL7040150 | 0.89 | ACE (0.54) | ACE | |
| SCHEMBL7042902 | 0.87 | KDM4E (0.55) | ACE | |
| Trifluoroacetamide SCHEMBL8247738 | 0.85 | ACE (0.56) | ACE | |
| 2,2,2-Trifluoroethanaminium SCHEMBL8247740 | 0.85 | ACE (0.58) | ACE | |
| SCHEMBL7041636 | 0.85 | KDM4E (0.64) | ACE | |
| SCHEMBL5568859 | 0.85 | DRD2 (0.45) | ACE | |
| 2,2,2-Trifluoroethanaminium SCHEMBL8208563 | 0.84 | ACE (0.56) | ACE | |
| Trifluoroacetamide SCHEMBL8208560 | 0.84 | ACE (0.54) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042288-B1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2007-11-07 | — | — | EP | disclosed |
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |