Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 20/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 19/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308811 | 0.86 | SLC6A4 (0.63) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5570107 | 0.85 | SLC6A3 (0.68) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4312344 | 0.85 | SLC6A3 (0.68) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4304058 | 0.85 | SLC6A4 (0.62) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4308879 | 0.83 | SLC6A3 (0.65) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4308852 | 0.83 | SLC6A3 (0.65) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4302254 | 0.83 | SLC6A4 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4305186 | 0.80 | SLC6A2 (0.74) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4307689 | 0.80 | SLC6A2 (1.00) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4318396 | 0.79 | SLC6A2 (0.72) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778639-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020049-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-02-23 | — | — | WO | disclosed |