Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14454206 | 0.77 | MEN1 (0.52) | JAK2JAK1TYK2STAT3JAK3 | |
| SCHEMBL1257037 | 0.77 | KMT2A (0.51) | JAK2JAK1TYK2STAT3JAK3 | |
| SCHEMBL1750786 | 0.76 | MKNK1 (0.49) | MKNK1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL949738 | 0.75 | MEN1 (0.52) | MKNK1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL2638129 | 0.74 | KMT2A (0.49) | MKNK1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL8465810 | 0.73 | MEN1 (0.57) | MKNK1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL21416877 | 0.72 | LCK (0.58) | JAK2JAK1TYK2STAT3JAK3 | |
| SCHEMBL15943680 | 0.70 | IDO1 (0.49) | MKNK1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL7936724 | 0.70 | CYP3A4 (0.52) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6833518 | 0.70 | SRC (0.53) | MEN1KMT2ACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753743-A1 | PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-02-21 | — | — | EP | claimed |
| WO-2005111018-A1 | PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-11-24 | — | — | WO | claimed |