Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.69 |
| ▸ | FLT4 | P35916 | 9/20 | 0.69 |
| ▸ | FLT1 | P17948 | 6/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.69 |
| ▸ | TEK | Q02763 | 4/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.69 |
| ▸ | RET | P07949 | 2/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
| ▸ | ERN1 | O75460 | 1/20 | 0.69 |
| ▸ | STK10 | O94804 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | FYN | P06241 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401636 | 0.91 | KDR (0.84) | KDRFLT4FLT1PDGFRBTEK | |
| SCHEMBL12809406 | 0.87 | KDR (0.77) | KDRFLT4FLT1PDGFRBTEK | |
| SCHEMBL13471998 | 0.83 | KDR (0.89) | KDRFLT4FLT1PDGFRBTEK | |
| SCHEMBL1401668 | 0.83 | KDR (0.89) | KDRFLT4FLT1PDGFRBTEK | |
| SCHEMBL3198096 | 0.83 | KDR (0.89) | KDRFLT4FLT1PDGFRBTEK | |
| SCHEMBL5566103 | 0.82 | KDR (0.69) | KDRFLT4FLT1PDGFRBTEK | |
| Cediranib SCHEMBL29368143 | 0.82 | KDR (1.00) | KDRFLT4FLT1PDGFRBTEK | |
| Cediranib SCHEMBL63147 | 0.82 | KDR (1.00) | KDRFLT4FLT1PDGFRBTEK | |
| Cediranib SCHEMBL29351458 | 0.82 | KDR (1.00) | KDRFLT4FLT1PDGFRBTEK | |
| Cediranib SCHEMBL29383181 | 0.82 | KDR (1.00) | KDRFLT4FLT1PDGFRBTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268230-B2 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2007-09-11 | — | — | US | disclosed |