Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.46 |
| ▸ | STK3 | Q13188 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877225 | 0.90 | ROCK2 (0.66) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL877789 | 0.90 | ROCK2 (0.61) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL877639 | 0.89 | ROCK2 (0.55) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL3580880 | 0.81 | RET (0.64) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL3794720 | 0.80 | ROCK2 (0.75) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL877574 | 0.80 | ROCK2 (0.67) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL877292 | 0.80 | ROCK2 (0.72) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL1721958 | 0.80 | ROCK2 (0.58) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL10221629 | 0.80 | PRKD3 (0.60) | ROCK2RETROCK1AURKBPRKD3 | |
| SCHEMBL3117095 | 0.79 | ROCK2 (0.62) | ROCK2ROCK1AURKBCSNK2A1STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |