Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 9/20 | 0.66 |
| ▸ | ICMT | O60725 | 7/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939557 | 0.92 | SERPINE1 (0.60) | SERPINE1ICMTL3MBTL1F2RL3 | |
| SCHEMBL4942794 | 0.91 | SERPINE1 (0.61) | SERPINE1ICMTL3MBTL1MAPK1F2RL3 | |
| SCHEMBL3948740 | 0.88 | SERPINE1 (0.82) | SERPINE1ICMTL3MBTL1MAPK1 | |
| SCHEMBL4937637 | 0.87 | SERPINE1 (0.80) | SERPINE1ICMT | |
| SCHEMBL3860766 | 0.87 | SERPINE1 (0.56) | SERPINE1ICMTL3MBTL1F2RL3 | |
| SCHEMBL4946406 | 0.87 | ICMT (0.60) | SERPINE1ICMTL3MBTL1MAPK1F2RL3 | |
| SCHEMBL3865483 | 0.86 | SERPINE1 (0.79) | SERPINE1ICMTL3MBTL1MAPK1F2RL3 | |
| SCHEMBL4940883 | 0.83 | SERPINE1 (0.61) | SERPINE1ICMTL3MBTL1MAPK1F2RL3 | |
| SCHEMBL3858380 | 0.83 | SERPINE1 (0.86) | SERPINE1ICMTL3MBTL1MAPK1 | |
| SCHEMBL4943358 | 0.83 | SERPINE1 (0.56) | SERPINE1ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844771-A2 | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) | Wyeth (US) | 2007-10-17 | — | — | EP | disclosed |