Olvanil

Olvanil

SCHEMBL557179

CCCCCCCC/C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 7/20 1.00
HPGD P15428 3/20 1.00
MAPT P10636 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
CYP2D6 P10635 2/20 1.00
MEN1 O00255 1/20 1.00
TP53 P04637 1/20 1.00
MTOR P42345 1/20 1.00
KMT2A Q03164 1/20 1.00
ALDH1A1 P00352 2/20 0.90
CYP2C9 P11712 1/20 0.87
ALOX15 P16050 1/20 0.87
CYP2C19 P33261 1/20 0.87
BLM P54132 1/20 0.87
PMP22 Q01453 1/20 0.87
EPHX2 P34913 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10835242 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10710550 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10711981 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
Olvanil SCHEMBL94262 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
Olvanil SCHEMBL537603 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10713542 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10711036 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
Olvanil SCHEMBL29381897 1.00 TRPV1 (1.00) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10883574 0.98 TRPV1 (0.96) TRPV1HPGDMAPTCYP1A2CYP3A4
SCHEMBL10885299 0.98 TRPV1 (0.96) TRPV1HPGDMAPTCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414427-A4 KAVALACTONE COMPOSITIONS AND METHODS OF USE SYNTA PHARMACEUTICALS CORP (US) 2004-08-18 EP claimed
EP-1414427-A2 KAVALACTONE COMPOSITIONS AND METHODS OF USE Kava Pharmaceuticals, Inc. (US) 2004-05-06 EP claimed
US-20030105159-A1 Kavalactone compositions and methods of use SYNTA PHARMACEUTICALS CORP. 2003-06-05 US claimed
WO-2003013436-A2 KAVALACTONE COMPOSITIONS AND METHODS OF USE KAVA PHARMACEUTICALS, INC. (US) 2003-02-20 WO claimed
EP-0306060-B1 PHARMACEUTICAL PRODUCTS PROVIDING ENHANCED ANALGESIA THE PROCTER & GAMBLE COMPANY (US) 1992-08-19 EP claimed
EP-0149545-B1 PHARMACEUTICAL PRODUCTS PROVIDING ENHANCED ANALGESIA THE PROCTER & GAMBLE COMPANY (US) 1989-12-27 EP claimed
US-4812446-A CAPSAICINOID AND SALICYLATE THE PROCTER & GAMBLE COMPANY (US) 1989-03-14 US claimed
EP-0306060-A2 Pharmaceutical products providing enhanced analgesia THE PROCTER & GAMBLE COMPANY (US) 1989-03-08 EP claimed
US-4599342-A MIXTURE OF CAPSAICIN WITH OPIOID THE PROCTER & GAMBLE COMPANY (US) 1986-07-08 US claimed
US-11844865-B2 Abuse-proofed oral dosage form Grünenthal GmbH (DE) 2023-12-19 US disclosed
EP-1765303-B2 ORAL TABLET SAFEGUARDED AGAINST ABUSE GRUENENTHAL GMBH (DE) 2022-11-23 EP disclosed
US-11224576-B2 Process for the production of an abuse-proofed dosage form Grünenthal GmbH (DE) 2022-01-18 US disclosed
US-20200397704-A1 ABUSE-PROOFED ORAL DOSAGE FORM Grünenthal GmbH (DE) 2020-12-24 US disclosed
US-10729658-B2 Process for the production of an abuse-proofed dosage form Grünenthal GmbH (DE) 2020-08-04 US disclosed
US-4812446-A CAPSAICINOID AND SALICYLATE THE PROCTER & GAMBLE COMPANY (US) 1989-03-14 US disclosed
EP-0306060-A2 Pharmaceutical products providing enhanced analgesia THE PROCTER & GAMBLE COMPANY (US) 1989-03-08 EP disclosed
US-4681897-A CAPSAICIN OR ANALOGUE WITH A NONSTEROIDAL ANALGESIC THE PROCTER & GAMBLE COMPANY (US) 1987-07-21 US disclosed
US-4599342-A MIXTURE OF CAPSAICIN WITH OPIOID THE PROCTER & GAMBLE COMPANY (US) 1986-07-08 US disclosed
EP-0149545-A2 Pharmaceutical products providing enhanced analgesia THE PROCTER & GAMBLE COMPANY (US) 1985-07-24 EP disclosed
EP-0149544-A2 Pharmaceutical products providing enhanced analgesia THE PROCTER & GAMBLE COMPANY (US) 1985-07-24 EP disclosed