Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 14/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5569044 | 1.00 | CYP2D6 (0.42) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5571645 | 0.88 | CYP2D6 (0.42) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5572387 | 0.88 | CYP2D6 (0.42) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5572188 | 0.82 | RET (0.33) | CYP2D6HSD17B10CYP3A4 | |
| SCHEMBL5571990 | 0.82 | OPRK1 (0.36) | CYP2D6HSD17B10 | |
| SCHEMBL5572531 | 0.82 | OPRK1 (0.36) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5568288 | 0.82 | OPRK1 (0.38) | CYP2D6HSD17B10 | |
| SCHEMBL5572251 | 0.80 | CYP3A4 (0.43) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5571772 | 0.78 | CYP2D6 (0.42) | CYP2D6HSD17B10ALDH1A1TSHRCYP3A4 | |
| SCHEMBL14027020 | 0.78 | CYP3A4 (0.39) | CYP2D6HSD17B10TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |