Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4914752 | 0.81 | MDM2 (0.74) | MDM2TP53 | |
| SCHEMBL4914758 | 0.81 | MDM2 (0.74) | MDM2TP53 | |
| SCHEMBL8272068 | 0.81 | MDM2 (0.59) | MDM2TP53HPGDHSD17B10 | |
| SCHEMBL5573053 | 0.78 | TP53 (0.46) | MDM2TP53 | |
| SCHEMBL4914047 | 0.66 | MDM2 (0.68) | MDM2TP53 | |
| SCHEMBL4914049 | 0.66 | MDM2 (0.68) | MDM2TP53 | |
| SCHEMBL8272067 | 0.66 | MDM2 (0.53) | MDM2TP53 | |
| SCHEMBL4912863 | 0.64 | MDM2 (1.00) | MDM2TP53HSD17B10 | |
| SCHEMBL4912856 | 0.64 | MDM2 (1.00) | MDM2TP53HSD17B10 | |
| SCHEMBL4912554 | 0.63 | MDM2 (0.65) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |