Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570568 | 0.84 | TP53 (0.62) | TP53MDM2KDM4EGAAMAPT | |
| SCHEMBL4913263 | 0.82 | MDM2 (0.72) | TP53MDM2 | |
| SCHEMBL4913256 | 0.82 | MDM2 (0.72) | TP53MDM2 | |
| SCHEMBL5573121 | 0.78 | MDM2 (0.47) | TP53MDM2 | |
| SCHEMBL4916051 | 0.76 | MDM2 (0.73) | TP53MDM2 | |
| SCHEMBL4916054 | 0.76 | MDM2 (0.73) | TP53MDM2 | |
| SCHEMBL12017330 | 0.66 | MDM2 (0.51) | TP53MDM2 | |
| SCHEMBL12017329 | 0.66 | MDM2 (0.51) | TP53MDM2 | |
| SCHEMBL4911242 | 0.66 | TP53 (0.68) | TP53MDM2 | |
| SCHEMBL8272070 | 0.66 | MDM2 (0.57) | TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |